![]() It has been suggested that endogenous pyrogens released by local inflammatory effects of Salmonella typhi endotoxin may sustain the pyrexia in typhoid fever. Although the single dose of 3 g for one day was successful in one case, the dose was increased to 4 g in four cases, with satisfactory responses being achieved in three cases ( Fig. The fever subsided within four days in nine cases and within six days in three cases ( Fig. So, the single dose of 3 g for two days was evaluated in twelve cases. However, a single dose of 2 g for two days failed in one case. ![]() ![]() Initially, the authors evaluated a single dose of 2 g for three, days in two cases: the results were excellent. In addition, it possesses a long serum half life which permits single dose therapy in an inpatient or outpatient setting. The gallbladder also becomes a source of the organisms in chronic carriers. Increased biliary excretion is desirable in the treatment of typhoid fever, because the gallbladder contains a large number of bacilli and excretes them even in the acute stage. Second, it has a high level of biliary excretion. 4), and also superiority over ampicillin and other cephalosporin in experimental Salmonella typhimurium infection. ![]() Ceftriaxone, a new parenteral cepalosporin, has some properties which may make it particularly useful in the treatment of typhoid fever.įirst, it has excellent in-vitro activity against most clinical isolates of Salmonella spp. ![]()
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